Acquire & Analyze - Multi-Channel Data Acquisition & Integrated pH Control
Designed for Transepithelial Electrophysiology Data AcquisitionACQUIRE & ANALYZE is a specialized data acquisition and analysis system for measuring bioelectrical properties in epithelial tissues or cell layers on permeable membranes, used with VCC MC2, MC6, or MC8 voltage/current clamps. Designed specifically for transepithelial electrophysiology, it records and plots voltage, current, and transepithelial resistance (TEER) in real time from up to eight tissues, eliminating the need for post-processing to calculate TEER.
The Windows®-based software provides an intuitive interface, allowing users to set parameters, select data collection rates, and generate compact files with minimal effort. By combining hardware, cables, and optimized software, it simplifies and enhances electrophysiological measurements for targeted research applications.
The Windows®-based software provides an intuitive interface, allowing users to set parameters, select data collection rates, and generate compact files with minimal effort. By combining hardware, cables, and optimized software, it simplifies and enhances electrophysiological measurements for targeted research applications.
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Product Description
Acquire & Analyze — Multi-Channel Data Acquisition and Integrated pH Control
Acquire & Analyze 3 is our next-generation acquisition platform for Ussing chamber and epithelial transport research. Run up to 8 channels simultaneously, control the pH EpiStat titrator in closed loop, and capture synchronized ISC, Rt, pH, and voltage data with automated event logging and continuous backup.
Key Features
- 8 Independent Channels: Simultaneous acquisition with synchronized traces (ISC, Rt, pH, Voltage).
- Integrated pH Control: Built-in closed-loop control with the pH EpiStat titrator—no external software required.
- Real-Time Adjustments: Change gain, offsets, and apply references per channel without interrupting acquisition.
- Automated Event Logging: Titrations, voltage steps, annotations, and calibration steps are timestamped and saved automatically.
- Guided Calibration Wizard: Streamlined electrode and amplifier standardization for consistent cross-channel data.
- Multi-Threaded Graphing Engine: Smooth live plotting and responsive controls during long experiments.
- Continuous Auto-Save: Redundant background saving to protect long recordings.
- Backwards Compatibility: Works with EasyMount P2300/P2400 chambers and the VCC MC8 amplifier.
- Flexible Exports: CSV/TXT plus optional PDF summaries with event overlays and embedded metadata.
What’s New in Version 3
| Area | New in A&A 3 |
|---|---|
| Throughput | Expanded from 4 to 8 simultaneous channels. |
| pH Control | Integrated closed-loop pH via pH EpiStat with refined PID behavior and minimal overshoot. |
| Workflow | Unified ribbon for VCC + titrator control; real-time per-channel adjustments without stopping. |
| Calibration | New Calibration Wizard with stepwise guidance and automatic verification. |
| Data Integrity | Continuous auto-save, recovery prompts, and detailed event/metadata embedding. |
| Visualization | Multi-threaded plotting, synchronized cursors, event overlays, and faster refresh. |
Technical Highlights
- Unified Control Surface: Amplifier and titrator controls live in one interface with live status indicators (RUN/STOP/SYNC).
- Synchronized Event Markers: Titration additions and reference changes appear inline on traces with timestamps.
- Channel-Specific Gain & Reference: Adjust per channel on the fly; global reference application supported.
- Lower Baseline Noise: Improved stability and drift handling across long runs.
- Metadata-Rich Exports: Chamber IDs, tissue notes, slider IDs, titration events and timing included in output files.
Scientific and Operational Advantages
- Higher Throughput: True 8-channel acquisition enables parallel conditions and replicates.
- Better Reproducibility: Closed-loop pH, guided calibration, and synchronized event logging improve repeatability.
- Time Efficiency: Real-time adjustments eliminate stop-and-restart interruptions.
- Traceability: Automatic audit trail of interventions, titrations, and annotations per channel.
- Data Security: Continuous auto-save protects long recordings and multi-hour studies.
Technical Specifications
| Supported Channels | Up to 8 simultaneous channels |
| Signals | ISC, Rt, pH, Voltage (per channel) |
| Sampling | Up to ~200 sps/channel (typical operating range; project-dependent) |
| pH Control | Integrated pH EpiStat titrator (closed-loop, PID-based) |
| Calibration | In-app wizard for electrodes & amplifier channels |
| Export Formats | CSV, TXT, optional PDF summaries with event overlays |
| OS Compatibility | Windows 10/11 (64-bit) |
| Connectivity | USB 2.0 or Ethernet (device-dependent) |
| Supported Hardware | VCC MC8 Voltage Current Clamp; EasyMount P2300/P2400 Chambers; pH EpiStat titrator |
Compatibility & What’s Included
- Compatibility: EasyMount P2300/P2400, VCC MC8, pH EpiStat titrator.
- Included: A&A 3 software license, user guide, and quick-start calibration checklist.
- Optional: Training session with our applications team; remote setup assistance.
Frequently Asked Questions
Can I run 8 channels and pH control at the same time?
Yes. A&A 3 is designed to acquire up to 8 channels while operating the pH EpiStat titrator in closed loop. Event markers record pH corrections alongside all traces.
Do I need to pause acquisition to adjust gain or apply a reference?
No. You can perform per-channel gain/offset changes and apply references during acquisition.
What export formats are available?
CSV/TXT with embedded metadata and event timing; optional PDF summaries with event overlays for reports.
Is Aacquire and Analyze 3 compatible with my existing Physiologic Instruments hardware?
Mostly Yes. A&A 3 supports the VCC MC8, EasyMount P2300/P2400, and the pH EpiStat titrator. If you are using the older system (PI-720P), this equipment will need to be upgraded to the U-100 for this new software to work.