The Multi-Channel Voltage Current Clamp with OptiGain is a multi-channel voltage/current clamp designed to be a flexible tool for studying ion transport mechanisms by in vitro epithelial tissues. It provides the capability to control either the voltage or the current across epithelial tissues, thereby enabling one to measure electrophysiological responses to drugs, hormones, and/or ion substitutions as well as to compare measurements of ionic flux with the short-circuit current. The voltage/current clamp is suitable for use with both "leaky" and "tight" epithelia, tissue samples or cell culture, and works for a very wide range of tissue area. The optiGain feature enables the user to optimize the instrument for the characteristics of the tissue under study by setting the current gain and fluid resistance compensation range from a pair of switches located on the front panel. This feature is unique to equipment by Physiologic Instruments.

The Multi-Channel Voltage Current Clamp offers these features: 1) A built-in pulse generator for monitoring of the tissue conductance/resistance (TEER). 2) Up to eight (depending on the model) independently controlled voltage/current clamp channels. 3) Digital readout of the transepithelial voltage or current. 4) Compensation for electrode asymmetry potentials over user selectable ranges of ±10 mV or ±100 mV. 5) Automatic compensation for voltage errors due to the resistance of the fluid in series with the epithelium - fluid resistance compensation (FRC). 6) The ability to clamp either the voltage or current to any dc level in the range ±100 mV or uA. 7) A Master Control switch that permits "one-touch" control of all clamp units. 8) Recorder outputs for continuous monitoring of the transepithelial voltage and current. 9) A pulse generator output providing +, - or bipolar pulses. 10) An external command signal input to allow an arbitrary waveform to be clamped. 11) A remote control interface jack to allow the Multi-Channel Voltage Current Clamp to be controlled directly by computer using the ACQUIRE & ANALYZE© data acquisition and analysis system or other such remote interface. 12) optiGain - switch selectable current gain and fluid resistance compensation range.

8-Channel Voltage Clamp using 8 Channels (Model:  VCC MC8-8S) Includes: (1) VCC MC8 MultiChannel Voltage/Current Clamp, (8) MC_601 Voltage/Current Clamp Channels, (8) DM_MC6 Input Modules with Dummy Membrane, (1) optiGain for switching gain and fluid resistance ranges.  Can be expanded up to (8) clamp channels using MC_601 plug in modules.

8-Channel Voltage Clamp using 6 Channels (Model:  VCC MC8-6S) Includes: (1) VCC MC8 MultiChannel Voltage/Current Clamp, (6) MC_601 Voltage/Current Clamp Channels, 6) DM_MC6 Input Modules with Dummy Membrane, (1) optiGain for switching gain and fluid resistance ranges.  Can be expanded up to (8) clamp channels using MC_601 plug in modules.

8-Channel Voltage Clamp using 4 Channels (Model:  VCC MC8-4S) Includes: (1) VCC MC8 MultiChannel Voltage/Current Clamp, (4) MC_601 Voltage/Current Clamp Channels, (4) DM_MC6 Input Modules with Dummy Membrane. (1) optiGain for switching gain and fluid resistance ranges.  Can be expanded up to (8) clamp channels using MC_601 plug in modules.

8-Channel Voltage Clamp using 2 Channels (Model:  VCC MC8-4S) Includes: (1) VCC MC8 MultiChannel Voltage/Current Clamp, (2) MC_601 Voltage/Current Clamp Channels, (2) DM_MC6 Input Modules with Dummy Membrane, (1) optiGain for switching gain and fluid resistance ranges. Can be expanded up to (8) clamp channels using MC_601 plug in modules.

 

OPERATIONS MANUAL PDF 

MODEL VCC MC2
MODEL VCC MC6
MODEL VCC MC8

The 6-Channel MultiChannel Voltage Current Clamp with OptiGain is a multi-channel voltage/current clamp designed to be a flexible tool for studying ion transport mechanisms by in vitro epithelial tissues. It provides the capability to control either the voltage or the current across epithelial tissues, thereby enabling one to measure electrophysiological responses to drugs, hormones, and/or ion substitutions as well as to compare measurements of ionic flux with the short-circuit current. The voltage/current clamp is suitable for use with both "leaky" and "tight" epithelia, tissue samples or cell culture, and works for a very wide range of tissue area. The optiGain feature enables the user to optimize the instrument for the characteristics of the tissue under study by setting the current gain and fluid resistance compensation range from a pair of switches located on the front panel. This feature is unique to equipment by Physiologic Instruments.

The 6-Channel MultiChannel Voltage Current Clamp offers these features: 1) A built-in pulse generator for monitoring of the tissue conductance/resistance (TEER). 2) Up to eight (depending on the model) independently controlled voltage/current clamp channels. 3) Digital readout of the transepithelial voltage or current. 4) Compensation for electrode asymmetry potentials over user selectable ranges of ±10 mV or ±100 mV. 5) Automatic compensation for voltage errors due to the resistance of the fluid in series with the epithelium - fluid resistance compensation (FRC). 6) The ability to clamp either the voltage or current to any dc level in the range ±100 mV or uA. 7) A Master Control switch that permits "one-touch" control of all clamp units. 8) Recorder outputs for continuous monitoring of the transepithelial voltage and current. 9) A pulse generator output providing +, - or bipolar pulses. 10) An external command signal input to allow an arbitrary waveform to be clamped. 11) A remote control interface jack to allow the Multi-Channel Voltage Current Clamp to be controlled directly by computer using the ACQUIRE & ANALYZE© data acquisition and analysis system or other such remote interface. 12) optiGain - switch selectable current gain and fluid resistance compensation range.

6-Channel MultiChannel Voltage Current Clamp options: 

VCC MC6-6S Voltage Current Clamp includes: (1) VCC MC6 voltage/current clamp, (6)  DM_MC6 input modules with integral dummy membrane, (6) MC_601 Voltage/Current Clamp channels, (1) optiGain for switching gain and fluid resistance ranges.  Can be expanded up to (6) clamp channels using MC_601 plug in modules.

VCC MC6-4S Voltage Current Clamp includes: (1) VCC MC 6 voltage/ current clamp, (4) MC_601 clamp modules, (4) DM_MC6 input modules with integral dummy membrane, and (1) optiGain for switching gain and fluid resistance ranges. Can be expanded to (6) clamp channels using plug in modules.  Can be expanded up to (6) clamp channels using MC_601 plug in modules.

VCC MC6-2S Voltage Current Clamp includes:(1) VCC MC6 voltage/current clamp, 2) DM_MC6 input modules with integral dummy membrane, (2) MC_601, (1) optiGain for switching gain and fluid resistance ranges. Can be expanded to (6) clamp channels using plug in modules.  Can be expanded up to (6) clamp channels using MC_601 plug in modules.

The VCC MC2 Voltage Current Clamp is a modular two-channel voltage/current clamp with clamp channels that are interchangeable with those of the VCC MC6 and VCC MC8. It includes an integral pulse generator and computer interface circuitry in a small 9.5” chassis while maintaining nearly all the features of the single channel VCC600. The instrument reduces the amount of lab bench space required for transepithelial experiments and interfaces perfectly with our new EasyMount two channel tissue and cell culture chambers described below. Option HV increases the output compliance to ± 35V DC. This is required only for certain types of experiments. Please consult the manufacturer. Each VCC MC2 includes two (2) single channel input boxes (DM MC6).

The 2-Channel Voltage Current Clamp offers these features: 1) A built-in pulse generator for monitoring of the tissue conductance/resistance (TEER). 2) Up to eight (depending on the model) independently controlled voltage/current clamp channels. 3) Digital readout of the transepithelial voltage or current. 4) Compensation for electrode asymmetry potentials over user selectable ranges of ±10 mV or ±100 mV. 5) Automatic compensation for voltage errors due to the resistance of the fluid in series with the epithelium - fluid resistance compensation (FRC). 6) The ability to clamp either the voltage or current to any dc level in the range ±100 mV or uA. 7) A Master Control switch that permits "one-touch" control of all clamp units. 8) Recorder outputs for continuous monitoring of the transepithelial voltage and current. 9) A pulse generator output providing +, - or bipolar pulses. 10) An external command signal input to allow an arbitrary waveform to be clamped. 11) A remote control interface jack to allow the 2-Channel Voltage Current Clamp to be controlled directly by computer using the ACQUIRE & ANALYZE© data acquisition and analysis system or other such remote interface. 12) optiGain - switch selectable current gain and fluid resistance compensation range.